Abstract 19553: Changes of Plaque CT Densities Evaluated by MDCT Have Inverse Relationships with Changes of LDL/HDL Ratio and Triglyceride Levels
Background: A body of evidences have been accumulated about ascertainment of plaque stabilization using invasive IVUS. However, the way of its evaluation by coronary CT angiography (CCTA) has not been well established. We assessed the hypothesis that CCTA has an ability to evaluate coronary plaque stabilization in terms of CT density according to the changes of risk factor profiles.
Method: Among the consecutive 1,124 cases examined by CCTA from Feb.2007 to Jan. 2010, 35 patients (male/female 23/12, 67 ± 8 years) were retrospectively analyzed who underwent CCTA twice at an interval of nearly one year (mean ± SD, 415.3 ± 118.4). Minimum CT density of the most distinguishable plaque (non-calcified or mixed) in the first CCTA was measured in the trans-axial MPR view using the equipment of computer workstation. The CT density at the same point in the second CCTA was also measured. The difference (second - first) was calculated and defined as “ΔCT”. Differences of risk factors such as FBS, HbA1c, t-chow, LDL, HDL, TG, LDL/HDL, Cre, eGFR were also defined as “ΔXXX” same as “ΔCT”. Data were analyzed by regression analysis.
Results: Among the variables measured, ΔLDL/HDL and ΔTG had weak but significant inverse correlations with ΔCT (p=0.02, R2=0.15 for ΔLDL/HDL and p=0.02, R2=0.16 for ΔTG) (Figure).
Conclusion: In conclusion, increase in plaque CT density correlated with decrease of LDL/HDL ratio and TG. This fact may propose the possibility of CCTA as a tool for evaluating plaque stabilization according to lipid profile modification.
- © 2010 by American Heart Association, Inc.