Abstract 19444: No significant difference in Outcomes between Patients with Pulmonary Hypertension due to Systolic versus Diastolic Left Ventricular Dysfunction
Heart failure (HF) is one of the leading causes of death in the United States. Two major classes of HF are diastolic and systolic. There is scarce data comparing the outcomes of these two groups in patients with severe pulmonary hypertension (PHTN). The aim of this study was to compare the mortality and re-admission rates in these two patient populations.
Hypothesis: There is no difference in the outcomes of patients with diastolic HF (DHF) with severe pulmonary hypertension compared to patients with systolic HF (SHF) with severe pulmonary hypertension.
Methods: This was a retrospective study. The electronic medical record system of the Montefiore Medical Center was used to gather patient information over the past ten years. Diastolic HF and systolic HF patients were identified by ICD-9 diagnosis code and those who had the latest EF > 50% or <= 40%, respectively were included in the study. Patients with only severe pulmonary hypertension (PASP >=60 mmHg) were considered. Mortality and cardiac re-admission rates up to five years were calculated.
Results: The number of DHF patients with PHTN was 326 and those with SHF and PHTN were 969. The mean EF in patients with DHF and severe PHTN was 62+/−5% and in patients with SHF and severe PHTN it was 30+/−8%. There was no significant difference in the mortality and cardiac re-admission rates up to five years between these two groups. The five-year mortality rate in DHF patients with PHTN was 77.0% versus 71.8% in patients with SHF and PHTN (p=0.29). The five year re-admission rate in DHF patients with severe PHTN was 64.1% vs. 60.8% (p=0.13) in SHF patients with severe PHTN.
Conclusions: There is no significant difference in the outcomes of patients with severe PHTN due to DHF or SHF.
- © 2010 by American Heart Association, Inc.