Abstract 193: Female Gender is Not Predictive of Hospital Mortality After Coronary Artery Bypass Graft Surgery
Background: Gender differences in mortality have previously been reported in patients undergoing coronary artery bypass graft surgery. However, whether gender differences exist in modern era of cardiac surgery remain to be elucidated.
Aim: to investigate whether there was a gender difference in hospital mortality after isolated CABG
Methods: We reviewed data from our prospective cardiac surgery database of all patients (n=2793) undergoing isolated CABG from January 2003 through December 2006 at a large university medical center. The Mann-Whitney test was used to test for differences in continuous variables between the male and female groups, while the Chi-square test was used for categorical variables. Stepwise Cox-proportional hazards regression analysis (with variables age, gender, congestive heart failure, atrial fibrillation, and preoperative creatinine) was used to identify independent predictors of hospital mortality.
Results: The mean age was 68±9.1yrs, and mean EuroSCORE was 6.91± 3.18. The overall mortality was 1.9%. Females were older (mean age 71 ± 8.5yrs, versus males: mean 67 ± 9.2ys, p < 0.0001) and had a higher left ventricular ejection fraction (F: 60% vs 55% in M, p < 0.0001). The overall incidence of CHF was 4.6%, with no significant difference between the two groups (F: 4.8% vs 4.6% in M, p = 0.92). Despite a higher EuroSCORE (F: 8 vs 6 in M, p < 0.0001) indicative of greater mortality risk, there was no significant difference in mortality between the two genders (F: 2.7% vs 1.7% in M, p = 0.15). The only independent predictor of hospital mortality was age at the time of surgery (HR 1.2, 95% CI 1.02 to 1.36, p = 0.0125).
Conclusions: Despite a higher EuroSCORE and older age among females, there was no significant difference between men and women in hospital mortality after coronary artery bypass graft surgery. In the modern era of cardiac surgery, gender is not predictive of hospital mortality after coronary bypass surgery.
- © 2010 by American Heart Association, Inc.