Abstract 19292: Growth-differentiation Factor-15 Contributes to Evaluation of Cardiovascular Risk in Healthy Elderly Men in Addition to Cardiovascular History, Risk Factors and Other Biomarkers
Recently, levels of troponin, NT-proBNP, Cystatin-C (CysC) and C-reactive protein (CRP) were found to provide incremental prognostic information beyond established risk factors for estimation of cardiovascular (CV) risk in the general population. Growth-differentiation factor-15 (GDF-15) is expressed at cellular stress and inflammation and predictive of CV risk in patients with heart failure and ischemic heart disease. We evaluated GDF-15 as a marker of CV risk in elderly healthy men in addition to traditional CV risk factors and biomarkers.
Methods: The study population originated from the Uppsala Longitudinal Study of Adult Men (ULSAM) where plasma at age 71 were available from 940 men out of whom 561 did not have cardiovascular disease (non-CVD) at baseline. Levels of GDF-15, high sensitivity troponin-T (hs-cTnT), NT-proBNP, CysC and CRP were determined by ROCHE assays on a COBAS analyzer. The mortality and morbidity data were collected from the Swedish Public Registries.
Results: The table present univariable and multivariable (adjusted for age, current smoking, BMI, systolic blood pressure, antihypertensive treatment, total cholesterol, HDL cholesterol, lipid-lowering treatment, type 2 diabetes, previous cancer and levels of hs-cTnT, NT-proBNP, CysC and CRP) associations (hazard ratios, 95% CI) between 1 SD increase of the level of GDF-15 and 10 year outcome concerning CV death, coronary heart disease (CHD) events and all CV events including stroke.
Conclusion: In elderly men, the level of GDF-15 is independently related to long-term cardiovascular morbidity and mortality regardless of previous CV disease and independent of the information provided by conventional CV risk factors and other biomarkers. Furthermore, GDF-15 is the biomarker providing the strongest prognostic information in healthy subjects without previous CV disease.
- © 2010 by American Heart Association, Inc.