Abstract 19244: Correlation Between Epicardial Fat and Coronary Calcium Score in Patients With Type 1 Diabetes Mellitus
Background: Epicardial adipose tissue (EAT) is a visceral fat depot located under the visceral layer of the pericardium. Previous studies showed a role of EAT and development of coronary atherosclerosis. Type 1 diabetic (T1D) patients have a increased risk in developing cardiovascular disease, caused by endothelial dysfunction and accelerated atherosclerosis. Coronary Calcium Score (CCS) is a marker of coronary atherosclerosis and is strongly correlated with coronary disease in T1D patients. Aims: Assess the correlation between the volume of EAT measured by 64-Multidetector Computed Tomography (MDCT) and Coronary Calcium Score in T1D patients.
Methods: We designed a transversal study including 86 T1D outpatients. All patients underwent MDCT (Siemens Sensation 64) between January 2007 and November 2009. We collected anthropometric, clinical and biochemical parameters. CCS was evaluated using well established protocol. Epicardial fat volume was measured by semi-automatic model. It was performed a manual trace of the visceral layer of the pericardium (2.0 mm axial images). EAT was quantified by calculating the volume of tissue with density range from −45 to −200HU.
Results: Mean (s.d) age 40 ±10 years, 47 (54.6%) men and BMI 25,2 ±3,5 Kg/m2. Hypertension was observed in 31 (36%) patients. C-reactive protein 3,16 ±4,4 mg/l, HbA1c 8,3 ±1,6%; fasting plasma glucose 157 ±90,3 mg/dL; total cholesterol 180,1 ±47,2 mg/dL and triglycerides 87,4 ±89,9 mg/dL. Mean epicardial fat volume was 87,6±41,4 cm3 and CCS was 71,8±208. A positive correlation (0,34; p<0,001) was found between epicardial fat and CCS.
Conclusions: There is a positive correlation between EAT and Coronary Calcium Score in T1D patients. This fat depot may be associated with paracrine effect on the coronaries, not related to glycemic control or systemic inflammation. Possibly, in the near future, EAT will be a helpful tool to assess cardiovascular risk.
- © 2010 by American Heart Association, Inc.