Abstract 19108: Methylated Arginines and Carotid Artery Intimal-Media Thickness: Results of the Gutenberg Heart Study
Background: Carotid artery intimal-media thickness (IMT) is a commonly used method to detect subclinical atherosclerotic and has been inversely related to cardiovascular (CV) prognosis. Methylated arginines like asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and monomethyl arginine (NMMA) are markers of CV disease.
Methods: We investigated the cross-sectional relations of arginine, ADMA, SDMA, and NMMA plasma concentrations with IMT in 5,000 participants of the Gutenberg Heart Study (GHS, age 56 ±11 years, 51 % male). The IMT was determined in the A. carotis communis. Arginine and methylarginines were analysed by LC-MS/MS.
Results: In univariate analysis ADMA (rho=0.161, p<0.001), SDMA (rho=0.145, p<0.001), and NMMA (rho=0.105, p<0.001) were moderately correlated to log IMT whereas arginine was not (rho=0.007, p=0.62). In multivariate linear regression models including age, gender, smoking status, stroke, SBP, CHD, BMI, log creatinine, log CRP, LDL and glucose only ADMA was related to log IMT (beta 0.0728, SE 0.0225, p=0.001).
Conclusions: The endogenous nitric oxide synthase (NOS) inhibitor ADMA is associated with IMT in the large community-based sample of the Gutenberg Heart Study. We conclude that endogenous NOS inhibition contributes to subclinical atherosclerosis determined by IMT.
- © 2010 by American Heart Association, Inc.