Abstract 19085: Prevalence and Correlates of Aortic Root Dilatation in Hypertensive Patients with Left Ventricular Hypertrophy (The LIFE Study) - Application of New Multivariate Predictive Models.
Background: Based on echocardiographic measurements of 1207 healthy individuals, Devereux et al. have recently derived multivariate predictive models for Sinus of Valsalva (SoV) diameter for height.
Methods: 774 patients with hypertension and left ventricular (LV) hypertrophy had the necessary baseline characteristics and echocardiographic 2D measurements of aortic root size to be included. These variables were used to identify patients with aortic root dilatation at the SoV (defined as a measured diameter greater than the predicted diameter plus 1.96·SEE). Predicted SoV diameter for height was calculated by 1.519+(age[years] ·0.010)+(height[cm] ·0.010)-(sex[1=M, 2=F] ·0.247). Clinical and echocardiographic characteristics were compared between patients with and without aortic root dilatation. Multivariate analysis was used to identify correlates of aortic root dilatation.
Results: The prevalence of aortic root dilatation was 13.3%. There were no difference in the prevalence of aortic dilatation between diabetics and non-diabetics and no difference between genders. Obese patients had a higher prevalence of aortic root dilatation (22.4% vs. 11.8%, p=0.001). Aortic root dilatation was associated with higher prevalence of aortic regurgitation (28.3% vs. 14.0%, p<0.001), lower systolic pressure (170±21 vs. 174±20 mmHg, p=0.03), higher diastolic pressure (98±12 vs. 94±12 mmHg, p=0.03), higher LV mass (LVM, 253±61 vs. 231±55 g, p<0.001), higher stroke volume (SV, 85±19 vs. 77±17 ml, p<0.001), lower pulse pressure (PP, 72±15 vs. 76±16 mmHg, p=0.01) and lower total peripheral resistance (TPR, 1814±439 vs. 2010±578 dynes·s·cm−5). Multiple linear regression analysis is presented in table.
Conclusions: In hypertensive patients with LV hypertrophy SoV dilatation is common. The prevalence of dilatation was higher in obese patients, and multivariate analysis showed that PP, SV and LVM predicted measured over predicted SoV diameter ratio.
- © 2010 by American Heart Association, Inc.