Abstract 18822: Acute Reperfusion Hemorrhage is More Reliably Detected With T2* Maps Than T2 Maps: A Cardiac Magnetic Resonance Study
Introduction: Recent investigations using T2-weighted CMR have shown that myocardial reperfusion hemorrhage (MRH) may be an independent predictor of poor LV remodeling. However, the presence of edema and refocusing effects associated with T2-weighted imaging can reduce the conspicuity of MRH.
Hypothesis: We hypothesize that T2* changes are more sensitive than T2 changes for detecting MRH.
Methods: Ischemia-reperfusion injury (3 hrs of LAD occlusion followed by reperfusion) was inflicted in 7 dogs. Serial CMR studies (1.5T) were performed, post-reperfusion, on days 2, 5 and 7. T2 and T2* maps were acquired using validated imaging approaches and infarction was confirmed with late-enhancement imaging (Figure 1). T2* and T2 values from hemorrhagic infarctions, non-hemorrhagic infarctions and remote myocardium were computed and compared (Table 1; p<0.05).
Results: Hemorrhagic regions showed 46±12% decrease in T2*, and 8.5±15% increase in T2 compared to the remote myocardium (p<0.005). Regions of non-hemorrhagic infarctions showed an insignificant 0.6±13% (p=0.83) increase in T2*, and 31±11% increase in T2 compared to the remote myocardium (p<0.005). Hemorrhagic regions showed 46% T2* decrease compared to the non-hemorrhagic regions (22±4ms vs 41±5ms, p<0.005), while T2 values decreased by only 16% (61±5ms vs 73±4ms, p<0.005).
Conclusion: We conclude that T2* maps, compared to T2 maps, provide a more sensitive approach for reliably detecting acute MRH.
- © 2010 by American Heart Association, Inc.