Abstract 18773: Red Cell Distribution Width is Independently Associated With Atrial Fibrillation in Hospitalized Patients With Heart Failure
Introduction: Red cell Distribution width (RDW) is increasingly being implicated as a prognosticator of outcomes in heart failure (HF) patients. Likewise, atrial fibrillation (AF) is a risk factor for poor outcomes in HF patients. The association between RDW and AF has not been previously investigated.
Methods: We studied 2,353 HF patients [Age: 64±15 years; 55% females; 76% African Americans, 14% Caucasians and 10% others] hospitalized between Jan to August 2008 at an urban health care center. Clinical and laboratory data were collected retrospectively. AF was defined by admission electrocardiogram. Multivariate adjusted logistic regression analysis was performed to analyze the association between admission RDW (analyzed as a continuous and a categorical variable in tertiles) and AF.
Results: Patients with AF (n=260) were older (70±14 Vs 64±15 years, p<0.001), more likely to be of Caucasian ethnicity (21.32% Vs 9.07% African Americans p<0.001), had lower systolic blood pressure (136±30 Vs 147±35 mm of Hg, p<0.001), higher heart rate (98±28 Vs 89±21 beats/min, p<0.001) admission RDW value (16.1±2.4 Vs 15.6±2.3, p<0.01) and hemoglobin level (12.4±2.3 Vs 12.0±2.1 g/dl, p=0.02). Results of the maximally adjusted analysis are shown in table.
Conclusion: The finding that RDW is independently associated with atrial fibrillation in patients hospitalized with heart failure is novel and needs confirmation. Our data do not offer an insight on potential pathophysiology
- © 2010 by American Heart Association, Inc.