Abstract 18612: Serum Adipocyte Fatty Acid-Binding Protein is Associated With Coronary Lesion Complexity in Patients With Coronary Artery Disease
Background: We have recently reported that circulating adipocyte fatty acid-binding protein (A-FABP) was independently associated with coronary atheroma volume determined with intravascular ultrasound; however, the quality of plaque, in other words, vulnerable plaque is thought to be a critical factor for future coronary event. We investigated whether serum A-FABP levels are involved in coronary lesion complexity in patients with stable angina pectoris (SAP).
Methods: Serum A-FABP levels were analyzed in 115 patients with SAP (69±10 years; 80% men). The patients were divided into two groups according to lesion morphology on coronary angiography:Simple lesions; the subjects having simple lesions only (n=34) and Complex lesions; the subjects having complex lesions with or without simple lesions (n=81). We also assessed serum A-FABP in 50 age- and gender-matched control subjects having no evidence of coronary artery disease.
Results: Serum A-FABP (ng/mL) in patients with complex lesions was significantly higher than that in patients with simple lesions and control subjects (23.4 [17.7 to 30.8] vs. 18.2 [12.2 to 24.7] and 15.1 [12.1 to 19.4], p<0.01). In subjects with SAP, serum A-FABP was significantly correlated with body mass index (r=0.434, p<0.01), HDL-C (r=-0.167, p=0.01), HOMA-R as a marker of insulin resistance (r=0.212, p=0.02), and tended to be correlated with the ratio of serum eicosapentaenoic acid, one of n-3 polyunsaturated fatty acids (PUFA) and arachidonic acid, one of n-6 PUFA (r=-0.162, p=0.08). Serum A-FABP was also significantly associated with angiographic scores expressing the plaque burden, such as extent score (r=0.208, p=0.02) and Gensini score (r=0.272, p<0.01). SAP Subjects with higher A-FABP (>20.3 ng/mL) had more complex lesions than those with lower A-FABP. (62% vs. 42%, p=0.08). Multiple logistic analysis demonstrated that serum A-FABP was independently associated with the presence of complex lesions, and adjusted-odds ratio for complex lesions of serum A-FABP level (per doubling) was 2.38 (95% CI, 1.013 to 5.604, p=0.04).
Conclusions: Seum A-FABP was significantly associated with coronary lesion complexity in patients with SAP. Circulating A-FABP might be a new predictor of coronary events.
- © 2010 by American Heart Association, Inc.