Abstract 18605: Differences in the Extent of Left Ventricular Dyssynchrony in Hypertrophic Cardiomyopathy; Importance of Hypertrophic type
Objective: We aimed 1) to investigate differences in left ventricular (LV) dyssynchrony according to types of LV hypertrophy in hypertophic cardiomyopathy (HCM) and 2) to relate it to LV mass index (LVMI).
Methods: Ninety HCM patients (mean age, 55±12years) were consecutively enrolled and assigned to one of the following 3 types - asymmetric septal hypertrophy (ASH, n=22), pure apical hypertrophy (ApHCM, n=57), and mixed ASH and ApHCM (mixed, n=11). LV dyssynchrony index (LVdys) was defined as standard deviation of time to peak radial strains from 6 myocardial segments at the papillary muscle level using 2D speckle tracking technique. LV mass was measured using area-length formula and indexed for body surface area.
Results:: LVdys was markedly lower in the ApHCM than the other 2 groups (47.8±36.6 vs, 136.1±53.2 and 163.9±79.7, both P<0.001. Figure A). With a cutoff value of 130msec as the upper limit of normal in LVdys, 63.6% in ASH, 3.5% in ApHCM, and 63.6% of mixed type had a LV dyssynchrony (P<0.001). As illustrated in Figure B, LVdys displayed a positive correlation with LV mass index (R=0.25).
Conclusion: Although global LV systolic function as assessed with LV ejection fraction is preserved, LV dyssynchrony in HCM is not uncommon with an exception in ApHCM. Given the close relation between LV dyssynchrony and prognosis, relatively good prognosis in ApHCM could be explained at least partly by the lower prevalence of LV dyssynchrony.
- © 2010 by American Heart Association, Inc.