Abstract 18565: Racial Differences In Early Repolarization Pattern from 82,050 Consecutive Subjects with Otherwise Normal Electrocardiogram
Introduction: Early-repolarization pattern (ERP) on the standard electrocardiogram is associated with increased risk of cardiovascular mortality in middle-aged subjects but mechanisms of this association are poorly understood.
Hypothesis: We hypothesized that current epidemiological characterization of this phenomenon in a large population would provide a starting point for investigation of mechanisms.
Methods: We retrospectively evaluated ECG findings in consecutive subjects who underwent electrocardiography in a large hospital system in the western United States (outpatient and inpatient) during Jan 1997- Apr 2010. All ECGs were over-read by clinical cardiologists within the hospital system. All normal ECGs plus ECGs with ERP (otherwise normal) were included in the analysis.
Results: Prevalence of ERP among subjects with otherwise normal ECGs (n=82,050) was 2.8% (n=2225). Subjects with ERP were younger (45±17 vs. 52±17 yrs, P<0.001), more likely to be male (83% vs. 43%, P<0.001) and had lower body mass index (25±5 vs. 27±6 Kg/m2, P<0.001). ERP was more likely to be observed among African Americans (26% vs.15%, P<0.001) and Asians (7% vs.5%, P<0.001); and less likely among Caucasians (58% vs. 70%, P<0.001). In a separate analysis of the under 40 age group (47% of total), all differences prevailed except for race. Hispanics were more likely to have ERP (11% vs. 6%, P<0.001), Caucasians less likely (54% vs. 62%, P<0.001) but there were no differences in distribution among African Americans or Asians.
Conclusion: In this large single-health system experience, subjects with ERP were distinguished by younger age, male gender and lower BMI. Higher propensity among non-Caucasians and resolution with advancing age in Hispanics but not African Americans or Asians warrants further investigation.
- © 2010 by American Heart Association, Inc.