Abstract 18425: Intracoronary Lipid Burden in Diabetic Patients Undergoing Cardiac Catheterization: Results from the COLOR Registry
Background: Multiple studies suggest that intracoronary lipid core occurs within soft plaque in vessels with positive remodeling. Patients with diabetes mellitus, especially those treated with insulin, often have more calcified plaque and vessels with negative remodeling, suggesting potentially lesser amounts of lipid core. We sought to identify differences in lipid core burden in diabetics (DM) and nondiabetics who underwent lipid scanning with the InfraReDx catheter (InfraReDx Inc, Burlington, MA).
Methods: 187 patients referred for catheterization underwent lipid scanning. 204 Vessels were analyzed according the lipid core burden index (LCBI) in the proximal 40mm of each vessel imaged. Patients were divided in four groups: non-DM (n=117), diet controlled DM (n=14), medically controlled DM (n=34) and insulin requiring DM (n=22). LCBI was measured for each patient and compared by ANOVA across groups.
Results: Of the 204 vessels scanned, 173 (85%) were adequate for analysis (LAD n=78, RCA n=54, LCx n=41). In the proximal 40mm of the vessels scanned, there were no significant differences across groups. The median (25th-75th percentile) LCBI was 54 (21–115) in non-DM, 65 (26–123) in diet controlled DM, 47 (14–87) in medically controlled DM and 64 (14–93) in insulin controlled DM (p=0.52). No significant differences existed with respect to the vessel analyzed.
Conclusions: In patients referred for coronary angiography, intracoronary lipid is common in the proximal segments of coronary arteries. There are no significant differences in lipid core burden between diabetic and nondiabetic patients and no significant differences regarding the manner of diabetes control.
- © 2010 by American Heart Association, Inc.