Abstract 18305: Over and Above Blood Pressure: Uric Acid Levels Independently Predict Left Ventricular Mass in Never-Treated Hypertension
Objective: Elevated levels of serum uric acid (UA) are linked to cardiovascular risk and predict the future development of hypertension. To date, it is unclear if the role of this molecule goes beyond hypertension development and extends to subsequent target organ damage. We sought to investigate the relationship of UA levels and left ventricular mass in a cohort of newly diagnosed, never treated hypertensives.
Methods: 1225 never-treated hypertensives were examined. Left ventricular mass index (LVMI) and relative wall thickness (RWT) were calculated by echocardiography. Left ventricular hypertrophy (LVH) was defined as a LVMI >125 g/m2 (men) or >110 g/m2 (women); 0.44 as cut-off value for RWT discerned eccentric from concentric LV geometry. UA levels were measured from fasting blood samples. Non-normal variables were log-transformed. Standard multiple linear regression analysis with LVMI as dependent variable, UA an independent variable and smoking status, sex, diabetes mellitus, age, total cholesterol, eGFR, MAP and CRP as covariates was performed.
Results: UA levels were significantly higher in LVH compared to normal ventricular mass (mean logUA 0.726 vs 0.687 for LVH and non-LVH respectively, P<0.001). In contrast, UA levels did not differ in respect to RWT; mean logUA 0.703 vs 0.706 for eccentric and concentric patterns respectively, P=0.702. A positive correlation between logUA and logLVMI (r=0.296, P<0.001) was observed, suggesting that increased urate levels are associated with a higher myocardial mass. UA levels independently predicted LVMI, after adjusting for multiple confounders, including mean arterial pressure (standardized regression coefficient β=0.068, P=0.023, adjusted R2=0.297).
Conclusions: Increased UA levels are associated with a higher myocardial mass in never-treated hypertensives.
- © 2010 by American Heart Association, Inc.