Abstract 18212: Masked Hypertension is Frequent in Obstructive Sleep Apnea Syndrome and not Associated with its Severity
Background: The prevalence of masked arterial hypertension seems to be high in patients with Obstructive Sleep Apnea Syndrome (OSAS). MH has been associated with a higher risk of cardiovascular events. The aim of this study was to evaluate the prevalence of MH and the different types of arterial hypertension (AH) in a large population of patients with OSAS .
Methods: Clinical blood pressure and twenty-four-hour ambulatory blood pressure monitoring were systematically performed in 253 consecutive patients with documented OSAS. MH was defined as a normal blood pressure (BP) in the clinic or office (<140/90 mmHg), but an elevated BP out of the clinic (ambulatory daytime BP or home BP>135/85 mmHg).
Results: Two hundred and fitfy-three subjects (mean age 51.3 ± 9.5 years, 83% of men, mean BMI 31.8 ± 5.8 kg/m2, mean Apnea-Hypopnea Index (AHI) 52.9 ± 28.5 %) with OSAS were included. Eighty-two patients (32%) had known AH. Among the 171 (68%) without known AH, 55 (32%) were normotensive, 25 (15%) had white coat AH, 52 (30%) had newly diagnosed AH and 39 (23%) had masked AH. Two-hundred eighteen subjects (86%) were treated with continuous positive airway pressure. Masked AH was not associated with the severity of OSAS (AHI and the percentage of total sleep time during which the oxygen saturation was < 90% (SaO2 < 90%). However, subjects with masked arterial hypertension had a worst metabolic risk profile compared to normotensive patients.
Conclusions: Masked hypertension is frequent and is associated with the metabolic syndrome in patients with treated OSAS.
- © 2010 by American Heart Association, Inc.