Abstract 18204: Comparison of Predictors of Arterial Stiffness in Never-treated Hypertensives
Introduction: Hypertension is associated with increased arterial stiffness. Arterial stiffness is a predictor of cardiovascular (CV) risk.
Hypothesis: We compared the effects of classic CV risk factors, Framingham risk score (FRS) and several circulating biomarkers on arterial stiffness in never-treated hypertensives.
Methods: We enrolled 1225 consecutive essential hypertensives (mean age 52.9±11.7 years, 728 men). Arterial stiffness was determined with carotid-femoral pulse wave velocity (PWV) using the Complior® device. C-reactive protein (CRP), D-dimers, plasminogen-activator inhibitor type 1, lipoprotein (a) and fibrinogen were measured.
Results: In stepwise multivariable regression analysis, PWV was significantly associated with FRS, systolic blood pressure (SBP), CRP, age, glucose, HR, triglycerides and presence of diabetes after adjustment for all the aforementioned confounders (p=0.005, p<0.001, p<0.001, p<0.001, p<0.05, p<0.01, p<0.05 and p<0.05, respectively; adjusted R2 of the model= 0.419). In further analyses we employed dichotomous outcome variable (PWV≥75th percentile [9.1 m/s]). Receiver operating characteristic (ROC) curves were generated to evaluate the ability of the best 5 predictors of PWV according to the model, namely FRS, SBP, CRP, age and glucose, to discriminate subjects with and without significant arterial stiffness (PWV≥75th percentile [9.1 m/s]). (Table)
Conclusions: Our findings reinforce age and blood pressure as being strongly associated with PWV. However, FRS, CRP and glucose are also associated with PWV. In fact, FRS and SBP had the best diagnostic performance for increased arterial stiffness, implying that the role of classic risk factors, as those in FRS, might be incremental to age and blood pressure in higher PWV levels.
- © 2010 by American Heart Association, Inc.