Abstract 18166: Chronic Hyperglycemia and Arterial Compliance and Distensibility: the Atherosclerosis Risk in the Communities Study
Background: Hyperglycemia has been associated with an increased risk of cardiovascular morbidity and mortality. Preliminary studies suggest that hyperglycemia is associated with an altered function of the arterial wall.
Hypothesis: Chronic hyperglycemia, as assessed by hemoglobin A1c (HbA1c), is independently associated with decreased arterial compliance and distensibility in the general population.
Methods: We examined the cross-sectional association between HbA1c and carotid compliance and distensibility using B-mode ultrasound examination of the carotid artery in 9,886 participants from the community-based Atherosclerosis Risk in the Communities (ARIC) study. We used logistic multivariable regression models to test the association between clinical categories of HbA1c (<5.7, 5.7-6.4 and ≥6.5% or diagnosed diabetes), and decreased carotid compliance and distensibility (lowest quartile of arterial compliance and distensibility).
Results: Our final study sample consisted of 1,160 persons with and 8,726 without a history of diagnosed diabetes (56.8±5.7 years, 56.2% female). Compared to non-diabetics with a HbA1c <5.7%, persons with HbA1c 5.7-6.5% had no increased odds of lower carotid compliance (OR=1.14, 95% CI 0.97-1.33) after adjustment for major cardiovascular risk factors (Table). Subjects with HbA1c ≥6.5% or diabetes had an increased odds of lower carotid distensibility (OR=1.56, 95% CI 1.33-1.83). Similar results were obtained for compliance.
Conclusion: Elevated HbA1c is associated with decreased arterial compliance and distensibility, consistent with the hypothesis that hyperglycemia contributes to vascular stiffness.
- © 2010 by American Heart Association, Inc.