Abstract 18107: Mediterranean Diet Modifies Beneficially the Metabolic Profile Among Elderly People With High Rates of Depression. The Ikaria Study.
Background: For centuries Ikaria has been an ideal place for relaxing. Recently, Ikaria island's residents show well above average age expectancy; which can be explained by the type of their diet. We investigated the association of Mediterranean diet(MD) on clinical status and cardiovascular risk profile of elderly men and women, living in Ikaria Island.
Methods: From June to October of 2009, we studied 343 men and 330 women, aged 65 to 100 years, permanent inhabitants of Ikaria. Adoption of the MD, using the MedDietScore (range 0-55), was evaluated against the presence of cardiovascular risk and lifestyle factors, anthropometric indices, physical activity and biochemical parameters. The metabolic syndrome (MS) was defined according to the NCEP ATP III criteria. Depressive symptoms were assessed using the short version of the Geriatric Depression Scale (GDS range 0-15).
Results: 23% of men and 19% of women reported known cardiovascular disease(CVD), 32% of men and 25% of women had diabetes, 75% of men and 68% of women had hypertension, 62% of men and 69% of women had hypercholesterolemia, and 29% of men and 30% of women were obese. More than 90% of the participants reported consistent to their dietary habits for the past 3-4 decades; while the mean MD score was 38±3 in both sexes. Participants in the higher tertile of GDS-score had higher prevalence of MS (66%vs. 53%, p=0.02), fewer years of education (7±1.5vs 8.5±1.4, p=0.05), higher prevalence of hypertension (66% vs. 58%, p=0.04), diabetes(27% vs. 20%, p=0.04), CVD (23% vs.16%, p=0.04), and lower fitness status, compared to those in the lower tertile of GDS-scale. Every 1-unit increase in GDS-score was associated with a 12% higher likelihood of having an additional CVD risk factor; while GDS was associated with the existence of MS (OR=1.072, p=0.016). When we stratified our analysis in the elderly with high depression values, we found that MD was inversely correlated to the number of MS factors (b=-0,219, CI=-0.17-0, p=0.05), after controlling for several cofounders.
Conclusions: Depression symptoms are positively associated with cardiovascular risk factors, CVD and MS prevalence in elderly. Adherence to MD seems to protect against the accumulation of MS factors in elderly people, even with high rates of depression.
- © 2010 by American Heart Association, Inc.