Abstract 18103: Medical Costs Associated with All Combinations of Metabolic Syndrome Components
Because metabolic syndrome (MetS) is a known risk factor for cardiovascular disease and diabetes, associated medical care costs should be elevated. However, the extent to which costs associated with each MetS component and combinations of components is not known. We identified 58,056 non-pregnant adults age 30 or older who had no prior evidence of diabetes and had all MetS components measured in 2003 or 2004, and who remained members of Kaiser Permanente Northwest for at least five years following the date that the last of the MetS components was measured (index date). We collected all subsequent inpatient, outpatient, and pharmacy cost data. We then compared annualized medical care costs across the number of MetS components present, for the presence of individual components, and for all possible combinations of MetS components, adjusting for age, sex and baseline costs. Subjects were a mean of 57+12 years and 45% were men. Patients with no MetS components incurred adjusted annualized total costs of $3932. Each MetS component was associated with additional annual costs indpendent of the other components ranging from $244 for presence of impaired fasting glucose (IFG) to $441 for hypertension. Low HDL plus IFG was a particularly potent combination (incremental costs of $2070), as was the four component combination of low HDL, hypertension, obesity and IFG ($2112). A CVD hospitalization was associated with additional annual costs of $5571 and development of diabetes with $2807. However, among patients who developed diabetes, annualized costs were already substantially elevated prior to diagnosis ($8065), increasing to $13096 after diagnosis. MetS components are individually and independently associated with higher medical costs primarily through the increased risk of CVD hospitalizations and incident diabetes. Accurate prediction of at-risk patients most likely to experience these resource-intensive conditions could substantially reduce health care costs.
- © 2010 by American Heart Association, Inc.