Abstract 18068: Effect of a One-Year Randomized Controlled Family Based Lifestyle Intervention (FBI) on Functionally Significant Adipokines in Obese Children
Context: Dysregulated production of adipokines participates in the pathogenesis of obesity-associated cardiometabolic disease (CMD). Although beneficial effects of short-term physical activity-based lifestyle intervention on adipokines have been reported, long-term prospective studies are scarce in children. The current study determined the long-term effects of a Family Based-lifestyle Intervention (FBI) program on functionally significant adipokines such as adiponectin, leptin and PAI-1 in obese children.
Methods: Overweight children (N=149), with an age-adjusted BMI 85%tile were recruited for a 1-year randomized controlled outpatient FBI-program that included enhanced physical activity and dietary counseling and behavior modifications. Anthropometry, OGTT, adiponectin (total and HMW), leptin and PAI-1 were measured at baseline, 6 and 12-months of intervention.
Results: Results from 55 subjects (age:10.1±1.1 years; BMI%tile: 97.7±2.3), who completed all the studies (baseline, 6 and 12-months) are included here. While leptin and PAI concentrations decreased (P<0.05), the concentration of HMW adiponectin increased (P = 0.05) along with an increase the ratio of HMW to T-adiponectin (P<0.05) in the intervention group. Leptin and PAI-1 tented to increase in the control group, whereas HMW adiponectin showed a steady decrease.
Conclusions: One-year FBI-program appears to be durable with sustained changes in functionally important adipokines such as adiponectin, leptin and PAI-1, related to insulin resistance, satiety and fibrinolysis respectively. The beneficial changes observed in this 1-year family-based study is encouraging and it underscores the usefulness of interventions involving the whole family in reducing risk factors for obesity-related CMD in children.
- © 2010 by American Heart Association, Inc.