Abstract 18034: Subclinical Atherosclerosis and Early Changes in Cardiac Systolic Function in Young Adults: A Cardiovascular Magnetic Resonance Study of Myocardial Systolic Strain
Background: Increased carotid artery intima media thickness (IMT) is a marker of atherosclerosis and in the elderly is related to left ventricular systolic dysfunction. We hypothesised that subclinical changes in cardiac systolic function may already be evident in early life in those with subclinical atherosclerosis.
Methods: We studied 42 individuals (26 females, 16 males) with a mean age of 30.70±5.89 (mean±SD) and without overt cardiovascular risk factors. Carotid IMT was measured as a marker of subclinical atherosclerosis using ultrasound. Cardiovascular magnetic resonance imaging was used to assess the left ventricle with tagging sequences to assess myocardial motion and strain. Images were analysed with CIM to quantify circumferential systolic strain. Demographic and anthropometric characteristics were measured as well as metabolic parameters and peripheral blood pressure.
Results: Individuals with higher carotid IMT had reduced myocardial circumferential systolic strain (r=0.443, P=0.003). Increased peripheral systolic blood pressure, peripheral pressure, glucose, age, BMI and WHR were all significantly associated with increased carotid IMT (P<0.01) and, furthermore, higher glucose, triglycerides, total cholesterol, low density lipoproteins and waist to hip ratio were all significantly associated with reduced myocardial strain (P<0.015).
Conclusions: In young adults without overt cardiovascular disease there are already relations between subclinical atherosclerosis and subclinical changes in cardiac systolic function. Cardiac and vascular structure and function are closely interrelated from early in life with associations that extend to those in the normal range of cardiovascular risk.
- © 2010 by American Heart Association, Inc.