Abstract 180: The Comparison of the Effect of Two Mechanical Chest Compressors on Coronary Perfusion Pressure and Resuscitation Outcome During CPR
Life-sustaining coronary blood flow could be created through effective chest compressions. The mechanical chest compressors have been utilized to improve resuscitation after cardiac arrest. In this study, we compared the effect of the ThumperTM compressor and the LucasTM, active compression-decompression devices, on coronary perfusion pressure (CPP) in a swine model of CPR. We hypothesized that the LucasTM device would achieve better CPP and therefore favor the outcome of CPR. Ventricular fibrillation (VF) was induced and untreated for 10mins in 9 male swine weighing 40±3kg. CPR was initiated using the LucasTM compressor in 4 animals and the ThumperTM compressor in 5 animals. Epinephrine (30 mg/kg) was injected intravenously at the 2nd minute of compression. Defibrillation was attempted after 5mins of CPR. If return of spontaneous circulation (ROSC) was not achieved, CPR was continued for 1min prior to a subsequent defibrillation attempt until ROSC or for a total of 15mins. CPP was continuously monitored. Significantly better CPP was observed in the LucasTM group. This was associated with a higher ROSC rate after the first defibrillation (100% vs 40%, chi-square test, p<0.05). A significantly reduced incidence of recurrent VF within 10mins after ROSC (0.25±0.50 vs 17.80±5.50, p<0.05) was observed in animals treated with the LucasTM device. In swine model of CPR, the LucasTM device produced a more effective chest compression than the ThumperTM compressor, contributing to an improved resuscitation outcome.
- © 2010 by American Heart Association, Inc.