Abstract 17954: C-Reactive Protein, Interleukin-6, Fibrinogen and Risk of Sudden Death in European Men. The PRIME Study.
Background: Although pathological signs of inflammation have been found in the coronary atherosclerotic and thrombotic lesions of most sudden death victims, whether or not low-grade inflammation is involved in sudden cardiac death risk at the population level remains unclear.
Objectives: To examine prospectively the association of baseline level of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL6) and fibrinogen with sudden death in asymptomatic European men
Methods: Among 9771 healthy men from Northern Ireland and France and who were participants of the PRIME Study, 664 had a first coronary heart disease (CHD) over 10 years including 50 sudden deaths, 34 non-sudden coronary deaths and 580 non-fatal CHD events. For each outcome, 2 matched controls were randomly selected from the initial cohort (nested case control study design). Results: There was a 3 fold increased risk (95% CI: 1.20-7.81) of sudden death between the upper and the lower third of IL6 after adjustment for baseline confounders in conditional logistic regression analysis. Neither hs-CRP (HR third vs. first tertile= 1.27; 95% CI: 0.51-3.17) nor fibrinogen (HR third vs. first tertile =1.90; 95% CI: 0.76-4.75) was associated with sudden death. For comparison, there was a six fold increased risk of non-sudden coronary death from the highest compared to the lowest tertile of fibrinogen, and a trend toward an association with higher CRP and higher IL6. All 3 inflammatory biomarkers were moderately but significantly associated with non-fatal CHD.
Conclusions: The current study suggests that IL6 but not hs-CRP or fibrinogen is an independent predictor of sudden death in initially healthy European men.
- © 2010 by American Heart Association, Inc.