Abstract 179: The Comparison of the Effect of Two Mechanical Chest Compressors on Coronary Perfusion Pressure and Outcomes of CPR With Selective Head Cooling
Selective head cooling has been confirmed to improve the coronary perfusion pressure (CPP) during CPR. Mechanical chest compressors have been utilized to improve resuscitation after cardiac arrest. In the present study, we investigated the effects of the LucasTM, an active compression-decompression device, in combination with selective head cooling on CPP and resuscitation outcomes in a pig model of CPR. We hypothesized that the LucasTM device in combination with selective head cooling would achieve better CPP and therefore favored the outcome of CPR when compared with ThumperTM compressor and selective head cooling. Ventricular fibrillation (VF) was induced and untreated for 10 mins in 10 male pigs weighing 40±3kg. Animals were randomized into two groups. CPR was initiated using either the LucasTM compressor or ThumperTM compressor, and selective head cooling was initiated coincident with CPR by a refrigerant delivered with humidified oxygen through the RhinoChill device. Epinephrine (30mg/kg) was injected intravenously at the 2nd minute of compression. Defibrillation was attempted after 5mins of CPR. If return of spontaneous circulation (ROSC) was not achieved, CPR was continued for 1min prior to a subsequent defibrillation attempt until ROSC or for a total of 15mins. Significantly higher CPP and better ROSC rate after the first defibrillation (100% vs 60%, chi-square test, p<0.05) were observed in the LucasTM group, this was associated with a significantly reduced incident of recurrent VF within 10mins after ROSC (0.60±1.34 vs 5.80±4.27, p<0.05) compared with the ThumperTM group. The LucasTM device produced a more effective chest compression than the ThumperTM compressor, contributing to an improved resuscitation outcome in this experimental setting.
- © 2010 by American Heart Association, Inc.