Abstract 17873: Neurocognitive Improvement after Carotid Artery Stenting Is Persistent Up to 1 Year in Patients with Chronic Occlusion or Critical Stenosis
Backgorund: Carotid artery stenting might improve 3-month neurocognitive function post-procedurally in patients with severe carotid artery stenosis (CAS) or occlusion (CAO), but the long-term effects were not clear.
Methods and Results: We prospectively enrolled 34 patients (13 CAS, 21 CAO) with objective ipsilateral hemisphere ischemia, in whom carotid artery stenting was attempted. A battery of 5 neuropsychological tests, which was applied prior to, 3 and 12 months after intervention, had been completed in 16 patients (7 CAS, 9 CAO). Procedural success was achieved in 5 of 9 CAOs and all CASs in these 16 patients. The demographics and baseline cognitive performances were similar between the successful (group 1, n=12) and failed (group 2, n=4) patients. Significant improvement in Alzheimer Disease Assessment Scale (ADAS) (pre 9.5±9.1 vs 3 month 7.9±8.1, p=0.074; pre 9.5±9.1 vs 12 month 7.8±7.2, p=0.015), Color Trail Test A (pre 110.0±66.5 vs 3 month 93.0±47.3, p=0.060; pre 110.0±66.5 vs 12 month 85.3±41.4, p=0.0006) and Color Trail Test B (pre 204.5±101.1 vs 3 month 166.8±61.3, p=0.04; (pre 204.5±101.1 vs 12 month 157.8±62.9, p=0.03) was seen in group 1, but not in group 2. The changes of ADAS from baseline to 12 month were also significantly different between groups 1 and 2.
Conclusions: Neurocognitive improvement after carotid artery stenting is persistent up to 1 year in patients in CAO and severe CAS patients with ipsilateral cerebral hypoperfusion.
- © 2010 by American Heart Association, Inc.