Abstract 17849: Influence of a Paclitaxel Coated Balloon in Combination With a Bare Metal Stent on Restenosis and Endothelial Function
Background: Different approaches of local intravascular drug delivery may influence endothelial and microvascular function. The aim of this trial was to study the influence of a Paclitaxel Coated Balloon in combination with a Bare Metal Stent (DCB+BMS) versus a Bare Metal Stent (BMS) or a Sirolimus-Eluting Stent (DES) on coronary restenosis and endothelial function.
Methods: This prospective trial included 77 patients with coronary de-novo lesions. The patients were randomly assigned to either one of the treatment groups. After 9 months, patients underwent angiographic follow-up including invasive measurement of coronary endothelial function by flow-wire.
Results: Quantitative coronary angiography revealed similar baseline parameters. Compared to the BMS group, in-segment late lumen loss was significantly reduced in the DCB+BMS group (0.27±0.43 mm vs. 0.58±0.54 mm, p=0.034) and the DES group (0.28±0.40 mm, p=0.045). Coronary flow reserve was significantly higher with the DCB+BMS treatment (3.16±0.97 vs. 2.42±0.99 [BMS], p=0.036) whereas the increase in the DES group did not reach the significance level (3.06±1.39, p=0.144).
Conclusions: The combination of DCB+BMS showed a similar late lumen loss reduction comparable to a DES. Furthermore, DCB+BMS lead to a significant improvement of microvascular function over time [ClinicalTrials.gov Identifier: NCT00473499].
- © 2010 by American Heart Association, Inc.