Abstract 17748: Impact of Triglyceride-Rich High-Density Lipoprotein Composition on Development of Angiographic Coronary Artery Disease
Background: Although high-density lipoprotein (HDL) is the urgent target for coronary artery disease, few data exist regarding how compositional changes in HDL can affect coronary artery disease in which the anti-atherogenic quality of HDL is not simply defined by the plasma HDL-C level. Therefore, we determine the roles of HDL composition in angiographically evaluated coronary artery disease.
Methods: A total of 218 patients (134 males, mean age of 61 ± 11) suspected coronary artery disease were enrolled, and coronary stenosis index (CSI) was estimated by angiography. Fasting lipid profiles without lipid drugs were analyzed by ultracentrifugation, and free cholesterol, cholesterol ester, triglycerides (TG) and phospholipids (PL) levels in each fraction were determined.
Results: Mean CSI was 10.8 and median was 8.0. CSI showed moderate positive association with plasma TG (p<0.05, R2 2%), and apoB (p<0.05, R2 2%), and negative association with HDL-C (p<0.01, R2 5%), and apoAI (p<0.001, R2 6%). In HDL composition, HDL-TG/PL ratio showed strong positive association with CSI (p<0.0001, R2 8%) and number of coronary vessel with significant (>75%) stenosis (p<0.0005, R2 6%). Also similar impact was observed in HDL-TG/ApoAI ratio (p<0.0001, R2 9% in CSI, and p<0.0005, R2 7% in vessel disease number). HDL-TG itself was weakly associated with CSI (p<0.05, R2 2%), and not with vessel disease number. These TG-rich HDL ratios were positively associated with CETP mass (p<0.01, R2 5%). HDL-TG/PL or HDL-TG/ApoAI showed no gender difference. TG-rich HDL ratios were significantly associated with metabolic syndrome associated indexes, such as plasma TG, RLP-C, apoB, or fasting glucose, but showed strongest association with coronary atherosclerosis among these.
Conclusion: These results demonstrated that TG-rich HDL composition is strongly associated with coronary atherosclerosis, and can suggest its role in atherogenesis, rather than a simple marker.
- © 2010 by American Heart Association, Inc.