Abstract 17733: Abnormalities in Left Atrial Structure and Function in the General Population
Background: Abnormalities in left atrial (LA) structure and function may be important cardiac traits. We determined the prevalence of increased LA end diastolic volume (EDV) or low LA emptying fraction (EF), and their associations with heart failure (HF) risk factors including left ventricular (LV) structure, in the general population.
Methods: Dallas Heart Study subjects who had cardiac MRI with a measurable LAEDV and LAEF were included (N = 1886). LAEF was defined as [(LAEDV — LA end systolic volume) / LAEDV] ×100 and LV concentricity as LV mass/LVEDV. Increased LAEDV was defined at ≥97.5th percentile [≥50 ml/m2 (men) and ≥46 ml/m2 (women)] and low LAEF at ≤2.5th percentile [≤39% (men and women)] of a healthy subpopulation. Multivariable linear regression tested associations with LAEDV or LAEF.
Results: An increased LAEDV or low LAEF was present in 9% and 7% subjects, respectively. Both LAEDV and LAEF were associated with systolic blood pressure, hypertension status, and natriuretic peptide levels (Table). In both univariate (Figure) and multivariate analysis adjusting for traditional risk factors and LVEF, LVEDV was the strongest correlate of LAEDV (p < 0.001) but was only weakly associated with LAEF (p = 0.02). In similar models, low LAEF (but not increased LAEDV) was associated with higher LV concentricity (p < .001).
Summary: Nearly 10% of the general population has increased LAEDV or low LAEF, traits which are associated with HF risk factors, LV enlargement (predominantly LAEDV) and concentric LV remodeling (low LAEF only). These data suggest that abnormalities in LA structure and function will be associated with an increased risk of HF in the general population.
- © 2010 by American Heart Association, Inc.