Abstract 17701: Serum Uric Acid and Cardiac and Vascular Structural Changes in a General Population in Northern Italy. The Vobarno Study.
Background: The relationship between serum uric acid (UA) levels and cardiovascular (CV) disease has been described since the late 19th century. The role of UA as an independent risk factor for CV events and its association with target organ damage (TOD) is however less clear. Aim of the study was to assess the relationship between UA and different forms of TOD in a general population in Northern Italy (Vobarno Study).
Methods: 385 subjects (age 56±9 yrs, 44% males, 64% hypertensives, 32% treated) underwent laboratory examinations and both clinic and 24 hours BP measurement (Spacelabs 90207). Left ventricular and carotid artery structure were assessed by ultrasound and carotid-femoral PWV was measured using Complior SP (Artech, Pantin, France).
Results: subjects with increased UA (defined as >6 mg/dl in [[Unsupported Character - ♀]] and >7 mg/dl in [[Unsupported Character - ♂]] were older, had greater BMI, higher BP, glucose, cholesterol and triglycerides levels and lower HDL cholesterol and estimated glomerular filtration rate (e-GFR)(MDRD). Subjects with increased UA had also increased arterial stiffness (PWV: 11.1±4.1 vs 13.3±3.7 m/sec, p<0.0001), and a slight, but statistically significant, increase in left ventricular mass index (LVMI) (38.7±10.6 vs 43.0±11gr/m2.7, p <0.05) and IMT (Meanmax 1.1±0.28 vs 1.2±0.29 mm, p <0.05). After adjusting for possible confounders, including also e-GFR, in a multivariable model, PWV was significantly greater in subjects with increased UA (11.1±2.41 vs 13.4±3.7 m/sec, p<0.001), while no significant difference in LVMI and IMT was observed. A significant correlation between UA levels and, respectively, PWV (r=0.279, p<0.001), LVMI (r=0.157, p<0.001), meanmax IMT (r=0.159, p<0.001) was observed. After adjusting for possible confounders in a multivariate model, serum UA levels were independently correlated to PWV, but not to LVMI and IMT.
Conclusions: in a general population sample subjects with increased serum uric acid levels have increased arterial stiffness, but comparable left ventricular anatomy and carotid artery structure. The increase in arterial stiffness might contribute to the higher risk of cardiovascular events observed in these subjects.
- © 2010 by American Heart Association, Inc.