Abstract 17687: Effect of Cardiorespiratory Fitness on Acute Inflammation Induced Increases in Arterial Stiffness in Older Adults
Introduction: Acute systemic inflammation or infection transiently increases arterial stiffness, while high levels of cardiorespiratory fitness are associated with decreased inflammation and arterial stiffness in older adults. We tested the hypothesis that high cardiorespiratory fitness would partially prevent the unfavorable effect of arterial stiffness produced by acute systemic inflammation in older adults.
Methods: Using a randomized double blind sham placebo-controlled design, 40 healthy older adults (male 20, female 20; age 67±5 yrs) were assigned to receive either an influenza vaccine (n=20) as a model to generate systemic inflammation or a sham vaccine (n=20). Subjects were divided into high fitness (34±6 ml/kg/min) or low fitness (26±3 ml/kg/min) group by peak oxygen uptake. C-reactive protein and interleukin 6 were measured as markers of inflammation and carotid-femoral pulse wave velocity, as an index of arterial stiffness, was assessed before and 48 hours after each vaccination.
Results: Compared with sham placebo, the influenza vaccination caused a significant increase in C-reactive protein (p=0.015) and interleukin 6 (p=0.043) compared with baseline vaccine. Carotid-femoral pulse wave velocity was significantly increased after influenza vaccination (9.4±1.7 to 10.3±2.1 m/s, p<0.05), but not sham vaccination (9.5±1.2 to 9.4±1.3 m/s, NS). Interestingly, the high fitness group had an attenuated increase in arterial stiffness compared to the low fitness group (Δ0.40.±0.13 vs. Δ1.31±0.39 m/s, p=0.04) after acute inflammation.
Conclusions: These findings show that acute inflammation significantly increases arterial stiffness in older adults, but these increases were attenuated in the high fitness group compared to the low fitness group. High cardiorespiratory fitness may have a cardioprotective effect in older adults exposed to acute inflammatory stimuli.
- © 2010 by American Heart Association, Inc.