Abstract 17683: Continuous Positive Airway Pressure Therapy Decreases Plasma Glucose Levels after the Glucose Load Even in Non-Diabetic Patients with Obstructive Sleep Apnea
Background: Much attention has been recently paid to the association between obstructive sleep apnea (OSA) and impaired glucose metabolism. However, little information is available on the effects of continuous positive airway pressure (CPAP), an established therapy for OSA, on plasma glucose levels in an oral glucose tolerance test (OGTT) in patients with OSA.
Methods: A total of 43 non-diabetic patients who underwent full polysomnography and who were diagnosed as having OSA with an apnea-hypopnea index (AHI) ≥20 were enrolled in this study. The patients underwent 75-g OGTTs at baseline and after 6 months. The patients were divided into the following 2 groups: 29 patients (CPAP group) who continued CPAP therapy for 6 months and 14 patients (non-CPAP group) in whom CPAP therapy could not be initiated because of intolerance of the therapy.
Results: The fasting glucose level increased significantly in the non-CPAP group, whereas it did not change significantly in the CPAP group. The plasma glucose level at 2 h after the glucose load decreased significantly after 6 months in the CPAP group, whereas it did not change significantly in the non-CPAP group.
Conclusions: CPAP therapy can decrease the plasma glucose level after the glucose load in non-diabetic patients with OSA, suggesting that CPAP therapy has favorable effects on glucose metabolism even in non-diabetic patients with OSA.
- © 2010 by American Heart Association, Inc.