Abstract 17599: Automated Quantification of Coronary Plaque using a Novel Dedicated Registration Tool: A Feasibility Study with Multi-Detector Row Computed Tomography and Intravascular Ultrasound
Objectives: To demonstrate the feasibility of automated quantification coronary plaque using dedicated software with a novel registration tool on multi-detector row computed tomography (MDCT) in a comparison with intravascular ultrasound (IVUS).
Methods: Patients who had undergone MDCT and IVUS were enrolled. Automated lumen and vessel contour detection was performed for both imaging modalities (Figure 1, panel II). Dedicated automated quantitative software (QCT) with a unique registration algorithm was used to fuse a complete IVUS run with a computed tomography angiography (CTA) volume using true anatomical markers (panel III). The novel registration algorithm enabled an accurate matching of both imaging modalities along the longitudinal and transversal axis of the coronary arteries. For each coronary artery, fusion-based quantification of atherosclerotic lesions was performed (panel IV). At the level of the minimal lumen area (MLA), percentage area stenosis, plaque burden and degree of remodeling was obtained on MDCT using lumen area, vessel wall area and corresponding reference lines. Additionally, mean plaque burden was assessed for the entire coronary plaque. Similar variables were derived from gray-scale IVUS images using quantitative IVUS software.
Results: In total, 51 patients (40 men, 58±11 yrs, 103 coronary arteries) were included. A total number of 146 lesions were identified and analyzed using both quantitative approaches. Fusion-based quantitative analysis showed good correlation between MDCT and IVUS for MLA (r=0.72, p<0.05). At the level of the MLA, both techniques were well-correlated for percentage area stenosis (r=0.79, p<0.05) and plaque burden (r=0.70, p<0.05). Mean plaque burden (r=0.64, p<0.05) and remodeling index (r=0.56, p<0.05) showed significant correlations between QCT and IVUS.
Conclusion: Automated quantification of coronary plaque on MDCT using a novel registration tool showed good correlations with IVUS.
- © 2010 by American Heart Association, Inc.