Abstract 17507: Associations Between a Parental History of Premature Cardiovascular Disease and Coronary Calcium and Carotid Intima-Media Thickness: The Coronary Artery Risk Development In Young Adults (CARDIA) Cohort
Introduction: A parental history of premature cardiovascular disease (pCVD) may increase the risk of early-onset coronary calcium (CAC>0) and common carotid intima-media thickness (IMT) >90%ile in offspring. We sought to investigate associations between parental pCVD and CAC>0 or IMT>90%ile in CARDIA participants and to determine if adjustment for long-term average levels of risk factors from young adulthood to middle age affects associations.
Methods: We studied participants from the NHLBI-funded CARDIA cohort who attended the year 20 exam. Participants were grouped by pCVD status: maternal history only, paternal history only, any parental history, and no parental history (referent). We used separate logistic regression models (unadjusted and multivariable-adjusted for baseline or average risk factor levels over 20 year follow up) to assess associations of parental pCVD and subclinical atherosclerosis.
Results: There were 2283 participants (57% female, mean age 45 years at the year 20 exam). In unadjusted models participants with any parental history of pCVD had a higher odds of CAC>0 than participants with no parental history (see Table). This was largely driven by the association of CAC>0 with a paternal history of pCVD, which was minimally attenuated by full adjustment. The association between parental pCVD and CAC > 0 was seen in whites (OR = 1.57; 95% CI, 1.02-2.41), but not in blacks (OR=1.2; 95% CI, 0.72-2.00). No associations between parental pCVD and IMT > 90%tile were observed.
Conclusion: These findings suggest parental pCVD is associated with early development of subclinical atherosclerosis. Further research is needed to understand potential racial differences in the association of parental pCVD with subclinical atherosclerosis.
- © 2010 by American Heart Association, Inc.