Abstract 17492: Associations of Penraxin 3 with Mortality After Stroke and White Matter Hyperintensities Volume
Objectives: Recent experimental studies have revealed that Pentraxin 3 (PTX3) is a novel inflammatory marker and has an important role in regulation of the inflammatory process. Furthermore, PTX3 has been associated with cardiovascular disease and mortality. We examined associations of PTX3, a vascular inflammatory marker, with mortality and white matter hyperintensities volume (WMHV) in patients with acute ischemic stroke.
Methods: Blood samples were collected from 376 patients admitted to the stroke unit with ischemic stroke. PTX3 plasma concentrations and WMHV were measured by ELISA and quantitative method, respectively. The patients were divided into tertile according to levels of PTX3. We used Cox-regression analysis to examine hazard ratios (HR) and 95% confidence interval (CI) of tertiles of PTX3 for all-cause mortality and multiple linear regression to examine the independent association of log-PTX3 and log-transformed white matter hyperintensities volume.
Results: During 4.6 years, 94 patients (25.0%) have deceased. Serum PTX3 levels were higher in deceased patients (median, 9.8 vs. 18.8, p < 0.001). Survival rates were different across PTX tertiles (p<0.001) (Fig). In Cox-regression analysis, compared with the first tertile of PTX3, adjusted HR of the second and third tertile for all-cause mortality were 1.65 (0.84–3.26), and 1.96 (1.02–3.78) (Table). Moreover, multiple linear regression analysis revealed that PTX3 is independently associated with log-WMHV (β=0.154, p < 0.001) after adjusting for traditional risk factors.
Conclusion: We found that PTX3 is associated with mortality after ischemic stroke as well as with white matter hyperintensities.
- © 2010 by American Heart Association, Inc.