Abstract 17333: Inflammatory Capacity Not Amount of Peri-Coronary Adipose Tissue Affects Atherosclerotic Leasions Formation in Patients With Stable Angina
Background: Extravascular inflammatory expression may adversely influence coronary lesion formation through outside-to-inside signaling. Maximal standardized uptake value (SUV) of 18-FDG detected by positron emission tomography is proportional to macrophage density. Accordingly, we examined peri-coronary adipose tissue (PAT) thickness (TH), radiodensity (RD) and inflammatory activity using FDG-PET/CT.
Methods: 34 consecutive, non-diabetic patients with angiographicaly confirmed coronary artery disease (CAD) underwent FDG-PET/CT. TH was measured in two perpendicular dimensions on axial cuts of the RCA, LAD and LCX. RD and SUV were measured in fat surrounding RCA, LAD and LCX on the sections corresponding to their proximal segments. SUV was also measured in subcutaneous fat (SC), visceral thoracic fat (VS) and epicardial fat over right ventricle (EPI). Similar measurements were taken in healthy volunteers matched for age and BMI (n=17). In CAD patients, associations of SUV with gender, age, body mass index (BMI), serum glucose, were further analyzed. Extent of CAD was determined by % stenosis using QCA in segments corresponding to PET/CT sections.
Results: There was no difference in TH between CAD and controls (table). On the contrary, RD and PAT SUV were significantly greater in CAD than in controls (table). SUV surrounding coronary arteries (PAT SUV) was also significantly greater than SUV in other fat locations for both CAD and controls (SC: 0.27; VS: 0.54; EPI: 0.59; RCA SUV: 1.11; LCX SUV: 1.26; LAD SUV: 1.30; p<0.0001). PAT SUV was not related to gender, age, BMI, or serum glucose, but was positively related to % stenosis of respective coronary artery (RCA 0.82; p<0.001; LCX 0.60; p<0.005; LAD 0.50; p< 0.05).
Conclusions: 1. Inflammatory activity of PAT reflected by RD and SUV, not its amount is greater in CAD patients, than in controls; 2. PAT SUV is greater than in SC, VS, EPI; 3. PAT SUV correlates with the extent of CAD, supporting outside-to-inside hypothesis.
- © 2010 by American Heart Association, Inc.