Abstract 17263: Likelihood of Developing Diabetes and Cardiovascular Disease in Metabolically Obese Normal Weight Individuals
Background: Metabolically obese normal weight (MONW) individuals are potentially at increased risk for development of diabetes and cardiovascular disease (CVD) despite their normal body mass index (BMI).
Objective: To determine the likelihood of developing diabetes and CVD in the MONW individuals among the participants of the San Antonio Heart Study.
Methods: We analyzed the data of individuals aged 25 to 64 years who did not have diabetes or CVD at the time of enrollment in the San Antonio Heart Study. A total of 1,726 participants fulfilling this criteria completed follow-up examination. We defined normal weight as BMI < 25 kg/m2, and metabolically obese individuals using different standard criteria: (a) 2 or more metabolic abnormalities by the 2005 American Heart Association (AHA)/National Heart Lung and Blood Institute (NHBLI) criteria, (b) 2 or more metabolic abnormalities by the 2009 “Harmonizing the Metabolic Syndrome” criteria, and (c) serum triglyceride levels ≥ 2 mmol/l and waist circumference ≥ 90 cm in men and ≥85 cm in women by the hypertriglyceridemic waist criteria. We performed logistic regression analysis to examine the odds of developing diabetes and CVD in MONW individuals relative to the odds in metabolically-healthy normal weight individuals.
Results: Among the participants who fulfilled inclusion criteria, 3 to 7.3% met the definition of MONW, using different standard criteria. The odds ratios of developing diabetes and CVD among MONW individuals relative to metabolically-healthy normal weight individuals are as shown in the following table.
Conclusions: MONW individuals have a higher likelihood of developing diabetes by AHA/NHBLI or “harmonizing the metabolic syndrome” criteria and developing CVD by all three criteria. Hypertriglyceridemic waist predicts the future development of CVD but not diabetes. Screening of MONW individuals should be routinely performed in clinical practice to institute appropriate preventive measures.
- © 2010 by American Heart Association, Inc.