Abstract 17172: Depressed Heart Rate Variability and Inflammatory Process in Sarcoidosis Patients.
Introduction: Sarcoidoisis (Sar) is a multisystemic disease characterized by extensive inflammation and disturbance of autonomic nervous system function. However, the effect of inflammatory process, in heart rate variability (HRV), which is a marker of autonomic nervous system function, remains unknown.
Hypothesis: In the present study we investigated the hypothesis that inflammation status is associated with depressed HRV in Sar patients.
Methods: Ninety five patients with Sar and fifty matched healthy subjects (Cl) were included in the study. Twenty minutes recording of heart rate was used in order to calculate the Standard Deviation of RR (SDNN) as an index of HRV. Serum levels of s-ICAM-1 were measured by ELISA.
Results: Patients with Sar had significantly lower values of SDNN compared to the Cl (38.52±13.37 vs 58.44±22.81, p< 0.05). Bivariate correlation showed that SDNN was significantly associated with the age of the patients (p<0.005, r=−0.344) and with sICAM-1 values (p<0.005, r=−0.355). Disease duration and cortisone use were not correlated with HRV indices.
Conclusions: These findings indicate that Sarcoidosis is associated with reduced heart rate variability and with increased inflammatory process. This autonomic nervous system imbalance can be used as a surrogate marker of disease activity and for the long term prognosis of Sarcoidosis patients.
- © 2010 by American Heart Association, Inc.