Abstract 17098: Smoking is an Independent Modifiable Risk Factor for Incident Heart Failure in Community-Dwelling Older Adults: Findings from a Prospective Population Study
Background: Although smoking is a well-established risk factors for coronary heart disease, little is known about the association between smoking and incident heart failure (HF). The objective of this study was to determine the effect of smoking on incident HF among community-dwelling adults ≥65 years in the Cardiovascular Health Study (CHS).
Methods: Of the 5338 CHS participants without prevalent HF, 2780 (52%) had a smoking history and 1483 were either current smokers or had smoked within <15 yrs. Participants (n=1297) who quit smoking for >15 years ago were classified as non-smokers (AHA Policy Statement: risk after abstinence >15 yrs = never-smoker). A multivariable Cox regression model was used to estimate the associations of quartiles of smoking pack-year (PY) with incident HF (reference, non-smokers) during 12 years of follow-up. The model was adjusted for demographics and other cardiovascular risk factors including intercurrent acute myocardial infarction occurring before incident HF (n=259).
Results: Participants (n=5338) had a mean (±SD) age of 73 (±6) years, 58% were women, and 15% African American. The unadjusted and multivariable-adjusted associations of smoking PY quartiles with incident HF are displayed in the Table. When smoking PY was used as a continuous variable, every 10 PY increase in smoking was associated with a significant 5% increase in the risk of incident HF.
Conclusions: In community-dwelling older adults, compared to never smokers and those who quit smoking >15 years ago, current smoking was associated with a significant increased risk of incident HF. The association seemed to be the strongest among those with >40 PY of smoking.
- © 2010 by American Heart Association, Inc.