Abstract 17069: Omega-3 Fatty Acids Administration Improves Arterial Wall Properties In Healthy Smokers.
Introduction: Smoking is associated with endothelial dysfunction and impaired fibrinolytic status. Omega-3 fatty acids can modify cardiovascular risk factors.
Hypothesis: In the present study we assessed the hypothesis that omega-3 fatty acids can improve endothelial function, arterial stiffness and fibrinolytic process in healthy smokers.
Methods: We studied the effect of a 12 weeks oral treatment with 2gr/day of omega-3 fatty acids in 13 healthy smokers (aged 27.5±2.90y) on two occasions (day 0: baseline and day 84). The study was carried out on two separate arms, one with omega-3 fatty acids (2 gr/day) and one with placebo according to a randomized, placebo-controlled, double-blind, cross-over design. Measurements were carried out before (pSm) and immediately after (Sm0) cigarette smoking. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery. Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) as a measure of arterial wave reflections. Circulating levels of plasminogen activator inhibitor type 1 (PAI-1) were measured by ELISA.
Results: At baseline measurements, compared to pSm, cigarette smoking caused an increase in AIx (0.64±13.02 % vs 5.48±10.05 %, p<0.05) and PWV (5.88±0.64 m/sec vs 6.30±0.76 m/sec, p<0.05) as well as a decrease in FMD values (7.22±2.54 % vs 5.45±2.60 %, p<0.05). Treatment with omega-3 fatty acids improved pSm values of: FMD (7.22±2.54 % vs 9.94±5.30 %, p<0.05), PWV (5.88±0.64 m/sec vs 5.35±0.86 m/sec, p<0.05) and AIx (.64±13.02 % vs −3.82±13.72 %, p<0.05) while there was no significant difference with placebo administration. We also found that, compared with placebo, treatment with omega-3 fatty acids, blunted the acute smoking-induced increase in PWV (0.423±0.33 m/sec vs 0.013±0.56 m/sec, p<0.05). Finally we found that pSm levels of PAI-1 were increased after omega-3 fatty acids treatment compared to baseline measurements (23.37±13.39 ng/ml vs 16.28±11.27 ng/ml, p<0.05).
Conclusions: Short-term treatment with omega-3 fatty acids improves endothelial function and vascular elastic properties of the arterial tree, an effect which is also accompanied by an improvement in the fibrinolytic profile in healthy smokers.
- © 2010 by American Heart Association, Inc.