Abstract 16980: Effects of Cranberry Juice on Endothelial Function and Arterial Stiffness in Volunteers with Coronary Artery Disease
Recently, there has been considerable interest in the use of dietary interventions for prevention and management of coronary artery disease. Epidemiological studies suggest an association between higher flavonoid consumption and lower cardiovascular risk, and clinical studies have shown improved vascular function following consumption of flavonoid-containing beverages. We conducted a randomized double-blind crossover study comparing the effects of double-strength cranberry juice (480 ml/day; 54% juice; 835 mg total polyphenols; 94 mg anthocyanins) to the effects of a calorie-matched placebo beverage on endothelium-dependent vasodilation and arterial stiffness in 44 men and women with stable coronary artery disease (32% women, age 62±10 years). Participants refrained from consuming other flavonoid-containing beverages and consumed each study beverage for four weeks with a two-week rest period between beverages. The order of beverage consumption was randomized. There was no difference in effect of cranberry juice and placebo beverage on brachial artery flow-mediated dilation, a measure of conduit endothelium-dependent vasodilation (p=0.66). Chronic cranberry juice consumption was associated with a reduction in carotid-femoral pulse wave velocity (8.3±2.3 to 7.8±2.2 m/sec) in contrast to an increase (8.0±2.0 to 8.4±2.8 m/sec) following placebo beverage consumption (p=0.003) and withdrawal of other flavonoid-containing beverages. Thus, we observed differential effects of cranberry juice on endothelial-dependent vasodilation and stiffness of the central aorta in patients with coronary artery disease. Our findings argue against improved endothelial function as a mechanism of reduced arterial stiffness in this setting. Further studies are needed to define the mechanisms and clinical implications of the vascular effects of cranberry juice consumption.
- © 2010 by American Heart Association, Inc.