Abstract 16917: Acute Consumption of Different Types of Oil Affects Significantly Proinflammatory Cytokines and Adhesion Molecules in Healthy Individuals
Background: Inter-cellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and tumor necrosis factor alpha (TNF-a) are implicated in the pathogenesis of atherosclerosis. However, the exact role of oil consumption on proinflammatory cytokines and adhesion molecules remains unknown. In the present study we assessed the acute effect of olive oil, soy oil, corn oil and cod liver oil on the aforementioned molecules in healthy individuals.
Methods: Sixty seven healthy volunteers were randomized to receive an oral amount (50 ml) of each type of oil. Inflammatory process was estimated by measuring the soluble form of VCAM-1, ICAM-1 as well as TNF-a by ELISA. Serum levels of the three markers were measured at baseline and 3 hours post oil consumption.
Results: Acute consumption of olive oil (362.6±165.9 to 312.6±147.8 ng/mL), soy oil (394.1±195.7 to 325.8±192.1 ng/mL) and cod liver oil (492.4±235.2 to 415.8±210.6 ng/mL) decrease not significantly VCAM-1 levels (p=NS for all). On the contrary, corn oil increased VCAM-1 levels even not significantly (from 431.6±259.2 to 432.6±208.0 ng/mL, p=0.9877). All types of oil decreased ICAM-1 levels. Cod liver oil (321.6±128.2 to 268.4±126.1 ng/mL, p=0.0275) appeared to be superior to others, while the effect of olive oil (285.7±113.6 to 223.3±65.6 ng/Ml, p=0.0133) and the effect of soy (283.9±113.8 to 216.3±106.5 ng/mL, p=0.0132) were beneficial secondarily. Not worth mentioning that corn oil had a significant effect on ICAM-1 levels (299.3±105.6 to 246.3±131.3 ng/mL, p=0.0392) controversially to its slightly negative effect on VCAM-1. Despite of the fact that olive (1.05±0.23 to 0.98±0.22 pg/ml, p=0.0327), soy oil (0.92±0.18 to 0.82±0.117 pg/ml, p=0.0012) and cod liver oil (1.24±0.60 to 1.08±0.60 pg/ml, p=0.0039) reduced significantly TNF-a levels, corn oil induced a non significant decrease in TNF-a levels (0.98±0.30 to 0.97±0.33 pg/ml, p=0.8766).
Conclusions: All types of oil reduced significantly adhesion molecules ICAM-1 and VCAM-1 levels. Moreover, all types of oil decreased significantly TNF-a levels except of corn oil. These findings indicate that the different types of oil may have important anti-inflammatory properties.
- © 2010 by American Heart Association, Inc.