Abstract 16773: Associations between Heart Failure and Cognitive Function
Introduction: Cognitive impairment can be detected in approximately one third of hospitalized heart failure (HF), mostly involving attention & executive functioning (A&EF). Both HF and cognitive impairment are associated with a high burden of morbidity and mortality. Problems with A&EF can also impact the patient's ability to manage complex medication and monitor symptoms to maintain health. It is not clear whether HF is also associated with problems with A&EF in the general population.
Hypothesis: We assessed the hypothesis that HF and markers of left ventricular (LV) function are associated with A&EF in a population-based study.
Methods: In a population-based cohort, the Hoorn Study, regular physical examinations were performed. In 308 individuals (aged 74 ± 5 years, 51% male, 28% had type 2 diabetes, and systolic blood pressure was 145 ± 19 mmHg), echocardiographic and neuropsychological measurements were performed in 2005-2009. HF was considered present if previously diagnosed or if signs and symptoms (questionnaires) were accompanied by objective evidence of LV systolic (ejection fraction <50%) and/or diastolic dysfunction (echocardiography/ ECG/ B-type natriuretic peptide). We divided total HF into HF with reduced or normal ejection fraction if the LV ejection fraction was <50% or not, respectively. The assessed markers of LV function (all associated with HF) are shown in the Table. Test scores measuring A&EF were standardised and averaged to obtain one cognitive outcome measure.
Results: HF was significantly associated with A&EF (Table). HF with reduced or normal ejection fraction were both associated with lower A&EF scores (the latter not significantly). More impaired markers of LV function were also associated with lower A&EF scores, however only significantly for left atrial volume index and B-type natriuretic peptide levels.
Conclusions: In conclusion, HF and markers of LV function were associated with worse A&EF in a population-based study.
- © 2010 by American Heart Association, Inc.