Abstract 16662: Serum Albumin Levels Predicts Ischemic Stroke in the Community
Objective: Low levels of serum (s-) albumin have been associated with cardiovascular diseases and death. In patients with acute stroke, low levels of s-albumin have been shown to be associated with increased mortality and to be predictive of heart failure in the general population. Levels of albumin have been linked to inflammatory activity and coagulation status. However, the association between s-albumin and the development stroke in the community is limited.
Methods: In a prospective, community-based study of 1048 elderly men without stroke or transient ischemic attack at baseline (mean age 71 years, the ULSAM study) the association between s-albumin and a combined endpoint of fatal and non-fatal ischemic stroke was investigated.
Results: During follow-up (median 8.8 years), 123 individuals suffered from ischemic stroke. In multivariable Cox-regression analyses adjusting for established risk factors for stroke (age, hypertension, diabetes, electrocardiographic left ventricular hypertrophy, atrial fibrillation, smoking and hypercholesterolemia), lower s-albumin was associated with increased risk of stroke (hazard ratio for 1-SD increase of s-albumin, 0.80, 95% CI 0.66-0.96, p=0.017). S-albumin levels also predicted ischemic stroke after further adjustment for variables reflecting inflammatory status (IL-6 and CRP). S-albumin was not associated with subarachnoid or subdural hemorrhage.
Conclusion: In a large community-based sample of elderly men, s-albumin predicted ischemic stroke, also after accounting for established risk factors and for variables reflecting inflammation status. Additional studies are warranted to investigate if s-albumin is a modifiable risk factor.
- © 2010 by American Heart Association, Inc.