Abstract 16616: Late Expansion of Thin-Strut Self Expanding Stents Designed for Non-Obstructive Vulnerable Plaque
Plaque rupture is an event with serious consequences for patients. Therefore, in order to prevent rupture (e.g. thin cap fibrous atheroma or TCFA), stents have been designed to induce a protective fibrous cap. We studied in a preclinical setting, a self-expanding thin-strut stent with low radial forces designed to induce minimal injury, especially for soft plaque-pacification. Our objective was to evaluate changes in stent- and artery size (diameter, area) in coronary arteries of swine, by repeated measurements over a period of 3 months by QCA, OCT (optical coherence tomography) and histology. The study group consisted of four animals with two coronary stents each (total nr of stents: n=8). At baseline, 7, 28 and 90 days, endovascular imaging (OCT, IVUS) and QCA were performed to assess lumen and stent size.
Results: QCA, OCT and IVUS showed a limited decrease in lumen diameter between 7 and 28 days possibly as a result of the increase in intimal thickening. At 90 days OCT data indicated that both stent and lumen diameter had effectively increased in size (p<0.045 and 0.015, 28 vs. 90 days,) while intimal thickness remained stable (0.22±0.06 and 0.21±0.05 mm, 28 vs. 90 days). Histology showed the typical benign response of a bare metal stent without overt inflammation or delayed healing.
Conclusion: This self-expanding thin strut stent seems to preserve luminal area at 90 days follow-up and can thus compensate for neointimal thickening.
- © 2010 by American Heart Association, Inc.