Abstract 16540: Aortic Valve Calcium Score is Independently Associated with All-Cause Mortality
Background: The presence of aortic valve (AV) sclerosis on echocardiography has been associated with an increased risk of mortality. AV calcification can be quantified during non-contrast cardiac computed tomography (CT) using the Agatston scoring
Methods:. We hypothesized that increased AV calcification would be associated with increased all-cause mortality and examined this relationship in a large cohort of patients who underwent non-contrast cardiac CT for coronary calcium scoring methods. We studied 6052 patients (33% women, mean age of 53±10 years) who underwent coronary calcium scoring as part of a prospective registry and were followed for a mean of 5.4±1.6 years. On the initial noncontrast CT using 3 mm slices, AV calcium was scored using the Agatston method. Patients were divided into four groups by AV calcium score, 0 (n=5570), >0 to 400 (n=436), >400 to 1000 (n=27) and >1000 (n=19). All-cause mortality was assessed through the Social Security Death Index. Multivariate Cox proportional hazards regression was utilized to adjust for coronary artery calcium score, aorta calcification, age, sex, hyperlipidemia, diabetes and smoking.
Results: There were 94 deaths. Survival in patients with 0 aortic valve calcium was 98.8% (n=67), >0 to 400, 96.1% (n=17), >400 to 1000, 81.5% (n=5), and > 1000, 73.7% (n=5). After adjustments for age, sex, hyperlipidemia, diabetes, smoking, coronary calcium score, and aorta calcification, Cox regression hazard ratios for all cause mortality, using no AV calcification as reference, were 1.18 (0.66–2.10), 3.74 (1.41–9.92) and 9.96 (3.74–26.48) in the respectively increasing aortic valve calcium groups.
Conclusions: Aortic valve calcification as detected by CT during coronary artery calcium screening is strongly associated with all-cause mortality independent of coronary artery calcification, aorta calcification, and standard risk factors.
- © 2010 by American Heart Association, Inc.