Abstract 165: Trpv1 Agonist Rinvanil Induces Pharmacological Hypothermia and Improves the Outcome of CPR in a Rat VF Model
Therapeutic hypothermia after resuscitation was recommended as a routine management by the AHA. However, the optimal cooling method still remains to be investigated. Studies have demonstrated that TRPV1 agonist increases skin vasodilation and decreases body temperature and reduces metabolism. In this study, we investigated the effects of TRPV1 receptor agonist Rinvanil on the outcome in a rat model of CPR. We hypothesized that Rinvanil could induce hypothermia therefore improve survival. VF was induced electrically in 10 male Sprague-Dawley rats and untreated for 6 mins. CPR was started 6 mins prior to defibrillation. Thirty mins after ROSC, animals were randomized to receive either saline vehicle or Rinvanil infusion. The starting dose of Rinvanil was 2.5 mg/kg/h. Dosage was gradually increased to 15 mg/kg/h over 6 hours. The control animals received the same amount of saline. Temperature and myocardial function were monitored for 6 hours and 7 day survival time was observed. Temperature decreased more than 2.5°C with infusion of Rinvanil (Figure 1). Post resuscitation myocardial function was significantly better in the Rinvanil group than that in vehicle group (P<0.05) (Figure 2). Survival was improved in the Rinvanil group when compared with vehicle group (116±76hours vs 20±13hours, P<0.05). TRPV1 receptor agonist Rinvanil induced hypothermia following ROSC and improved myocardial function as well as survival in this rat model of CPR.
- © 2010 by American Heart Association, Inc.