Abstract 16489: Associations Between Thyroid Stimulating Hormone Levels and Cardiovascular Risk Factors in Euthyroid Adolescents
Introduction: In adults, even subtle disturbances in thyroid function appear to be associated with an increased prevalence of cardiovascular risk factors; however, little is known regarding the relationships between thyroid function and cardiometabolic disturbances during childhood and adolescence.
Hypothesis:We assessed the hypothesis that, among euthyroid adolescents in the United States, thyroid stimulating hormone (TSH) levels are related to multiple cardiovascular risk factors including body mass index (BMI), blood pressure, fasting glucose, and total cholesterol.
Methods: Cross-sectional data collected from 12- to 19-year-old adolescents as part of the National Health and Nutrition Examination Survey (NHANES) from 2007–2008 were analyzed to determine the relationships between TSH and BMI z-score, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting serum glucose, and total cholesterol. Only subjects with a normal TSH level (0.35–5.6 uIU/mL) and without a history of thyroid disease, diabetes mellitus, or blood pressure/cholesterol medication use were included in the analysis.
Results: A total of 883 euthyroid adolescents were included in the analysis (mean age: 15.0±1.93 years, 52.5% males). In univariate analyses, significant positive linear relationships were observed between TSH and BMI z-score (r=0.10, P=0.002), SBP (r=0.11, P<0.001), glucose (r=0.15, P<0.0001), and total cholesterol (r=0.11, P=0.001). The relationship between TSH and BMI z-score remained significant after controlling for sex and race/ethnicity. Similarly, the associations between TSH and fasting glucose and total cholesterol remained significant after controlling for sex, race/ethnicity, and BMI z-score. However, the relationship between TSH and SBP was no longer significant after controlling for other variables.
Conclusions: Even with values of TSH in the normal reference range, high normal TSH values are associated with an increased prevalence of adiposity and other cardiovascular risk factors in U.S. adolescents.
- © 2010 by American Heart Association, Inc.