Abstract 16404: Ventricular Arrhythmias are Independent of LV Dysfunction in Left Ventricular Noncompaction
Introduction: Left ventricular noncompaction (LVNC) has been associated with ventricular arrhythmias. Little is known regarding the prevalence of, and risk factors associated with ventricular arrhythmias.
Methods: The cohort included LVNC diagnosed by CMR. Events were adjudicated by ICD interrogation. Proportional hazards model and Log rank tests were performed to evaluate for risk factors of arrhythmic events.
Results: Of 104 patients with LVNC, 31 patients underwent ICD implantation. The ICD patients had a mean age of 48±16 years, 42% were male, 53% had an EF <45% and 30% had EF <35%. Appropriate ICD therapy was delivered in 24% of patients and 60% had a ventricular event. The presence of Gadolinium uptake (RR=24.7 [1.01–7.1]; p=0.01) was associated with appropriate ICD therapy. Neither an EF < 45% (RR=0.55 [0.08–2.82]; p=0.47) nor an EF<35% (RR=0.29 [0.01–1.95]; p=0.22) were associated with more delivered therapy (Figure).
Conclusions: Ventricular arrhythmias are prevalent in LVNC. Sustained ventricular arrhythmias are independent of LV dysfunction in LVNC.
- © 2010 by American Heart Association, Inc.