Abstract 16364: The Triglycerides to High-density Lipoprotein Cholesterol Ratio, a Predictor of the LDL-C Particle Size, is Associated with Coronary Plaque Regression
Background: We reported that elevated body mass index (BMI) show delayed coronary plaque regression by statin. However, the underlying mechanisms are still unknown. The purpose of this study was to investigate the differences in changes in lipoprotein cholesterol and coronary plaque volume between patients with elevated BMI (≥25) and normal BMI (<25).
Methods and Results: 6-month prospective study was conducted in 116 coronary artery disease (CAD) patients receiving pravastatin. LDL particle size was estimated by triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C). There was no significant difference in changes of LDL-C between patients with elevated BMI (H group) and normal BMI (N group), (H; −15.2%, N; −10.9%, p=0.36), however, changes in HDL-C was significantly different (2.7% vs. 15.2%, p=0.01). While there was no significant difference in baseline TG/HDL-C (3.0 vs. 2.5, p=0.71), 6-month TG/HDL-C and change in TG/HDL-C were significantly different (3.1 vs. 2.1, p<0.05, 5.8% vs. −16.1%, p<0.05, respectively). A 3-fold greater decrease in plaque volume, as assessed by volumetric intravascular ultrasound, was observed in N group as compared with H group (−12.6% vs. −3.9%, p<0.05). No significant difference in changes of BMI between both groups (H: −0.8% vs. N: 0.2%). A model for prediction of coronary plaque regression was prepared.
Conclusions: This study demonstrated that regression of coronary atherosclerosis by statin therapy may be less pronounced in elevated BMI patients, corresponding to elevated TG/HDL-C, suggesting that TG/HDL, for predicting LDL particle size, may play a crucial role in coronary plaque regression.
- © 2010 by American Heart Association, Inc.