Abstract 16359: Sex Hormone and ST Level: Not Only Testosterone but Also Estrogen Modulate ST Segment
Background: We recently reported that ST level was significantly higher in men than women due to a marked increase in the ST level after puberty in men, and androgen-deprivation therapy in patients with prostate cancer significantly decreased ST level, suggesting that testosterone modulates ST segment. However, the influence of female sex hormone on ST segment has not been fully assessed in humans.
Methods and Results: Surface 12-lead ECGs recorded in 100 healthy young subjects (50 men and 50 women, mean age: 24.5 years) were studied. The plasma concentration of testosterone, estradiol and progesterone and the ratio of testosterone to estradiol (T/E) were measured in all subjects. The levels of 3 points of ST-segment, J-point (ST-J) and the level at 1/16th and 2/16th of the preceding RR interval of the following ST segment (ST-M and ST-E) were automatically measured in the precordial leads. All 3 ST segments were significantly higher in men than in women in all leads (p<0.0001). In men, ST segments showed a significant positive correlation with testosterone in lead V1-V2 and negative correlation with estradiol and positive correlation with T/E in lead V4-V6 (figure). In women, ST-segments showed a significant positive correlation with testosterone in lead V3-V5 and negative correlation with estradiol in lead V4-V6.
Conclusions: Both sex hormones, testosterone and estrogen, modulate ST segment in the different leads in the young men and women.
- © 2010 by American Heart Association, Inc.